A 12-day overland route from Salta into the Atacama and Uyuni takes you across high Andean passes, colorful altiplanic lagoons and the world-famous salt flats. Prepare for long drives, high elevations and simple nights in exchange for extraordinary high-altitude landscapes.
More ways to explore the area's outdoor wonders
You step out in Salta as the morning light slants across red rock and wind-scrubbed plains; the bus hums, tires eating miles of RN40 while the Andes slowly climb, taking you from lush valleys to the thin, bright air of the high puna.
Difficulty
challenging
Duration
12 days
Fitness Level
Moderate to high: be comfortable with long vehicle days and short high-altitude walks; cardiovascular fitness helps with thin air.
Wildlife
History
The route follows ancient Andean corridors used by pre-Columbian communities and later by colonial trade, leaving a mix of indigenous traditions and Spanish-era towns.
Conservation
High-altitude wetlands and flamingo habitats are fragile; stick to marked paths, avoid disturbing wildlife and limit single-use plastics to reduce impact.
Reserve your spot on the Group Tour to Argentine Northwest, Atacama & Uyuni today and enjoy a trusted, highly rated experience designed to help you make the most of your adventure.
Acclimatize before ascent
Spend at least 24–48 hours in Salta or lower-altitude villages to reduce altitude sickness risk before climbing above 3,500 m.
Hydration is non-negotiable
Drink regularly — aim for 3–4 liters per day at high altitude — and avoid excessive alcohol in the first days.
Sun and reflection protection
Bring high-SPF sunscreen, a wide-brim hat and UV sunglasses — salt flats and high plateaus intensify solar exposure.
Carry cash and spare time
ATMs are scarce on the altiplano; bring Argentine pesos and Bolivian bolivianos and allow buffer time for border and road delays.
Layered midweight jacket
Cold nights at altitude and windy afternoons require insulating and windproof layers.
High-SPF sunscreen & UV sunglasses
Strong UV and reflection from salt and snow make sun protection essential year-round.
summer
Hydration system (1.5–2 L)
Easy access to water reduces dehydration risk during long drives and short hikes.
Sturdy, broken-in hiking shoes
Good traction on salt crust, gravel tracks and rocky viewpoints keeps you steady.